Joint / Arthritis
Now Foods Sam-e Double Strength 400/200mg
NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.*
Dr Oz looked into SAMe Supplements and found that there is some research that shows that it works as well as certain prescription drugs.
SAM-e (S-adenosyl-L-methionine) is not an herb, vitamin, hormone, or dietary nutrient; it is a synthetic form of a chemical that is naturally produced by the human body. SAM-e exists in cells and is involved in a variety of essential biochemical processes, including cell maintenance and nerve function. It is considered to be a metabolite of the essential amino acid L-methionine. SAM-e is also known by many as ademetionine, S-adenosylmethione, SAM, and SAMe.
SAM-e supplements are marketed for use in connection with a variety of conditions including osteoarthritis, depression, fybromyalgia, and liver disease. Many individuals maintain that SAM-e is as effective for pain relief as aspirin, but does not produce the same side effects such as stomach irritation. It is also believed by some people to be more effective for relieveing depression than many common anti-depressants. Since SAM-e is not regulated by the FDA, it does not require a doctor's prescription. However, in other regions such as Europe, SAM-e is sold as a prescription drug for treating depression, arthritis, and liver disease.
SAM-e is normally produced in the liver from the amino acid methionine found in most healthy diets. Both folic acid and vitamin B12 are required for the synthesis of SAM-e, and deficiencies of either of these vitamins may result in low concentrations of SAM-e in the central nervous system. Lower than normal levels of SAM-e have been detected in individuals with liver cirrhosis, heart disease, Alzheimer's disease, and depression.
Suggested Benefits of SAM-e
While healthy people do not need to supplement with SAM-e researchers suggest that many people may benefit from this supplement. Suggested benefits of SAM-e supplementation include the following:
Osteoarthritis. A number of double-blind studies indicate that SAM-e may help individuals with osteoarthritis. Studies show that SAM-e may reduce stiffness, pain and swelling in arthritic joints, as well as improve overall joint health. Results of some studies even go as far as to suggest that SAMe may be as effective in some instances as ibuprofen and naproxen. However, there is no evidence that SAMe will be effective in any form of arthritis other than osteoarthritis.
Liver Cirrhosis. Preliminary research indicates that SAM-e may also be helpful for various liver conditions including cirrhosis. In one trial, people with liver cirrhosis caused by alcoholism who took SAM-e for two years experienced a nearly 50 lower death rate and/or liver transplantation rate, compared with study participant who received a placebo. The results of this trial, however, where not statistically significant. The results of similar trials conducted using people with less severe forms of cirrhosis has yielded more promising results.
Fibromyalgia. Preliminary research suggests that SAM-e may assist those with fibromyalgia. In one double-blind study in which people with fibromyalgia were given supplemental SAM-e showed beneficial effects, such as a decrease in fatigue, pain sensation, and stiffness. Study participants also noted a significant improvement in mood. Notwithstanding, not all studies have reported such beneficial results.
Depression. SAMe may be helpful for promoting mood and emotional well-being and has been used by some people for the treatment of depression. This has resulted in a series of preliminary studies using oral and parenteral SAMe to treat depression. While the results of these studies are promising they are still inconclusive.
Additional research suggests that SAM-e may also be helpful for cholestasis, liver injury due to alcohol, Gilbert's syndrome and migraines. It may also anti-depressant and hepatoprotective activities.
Suggested Usage: As a dietary supplement, take 1 tablet 1 to 2 times daily, preferably on an empty stomach. Refrigeration recommended after opening.
Supplement Facts
Serving Size 1 Tablet
Servings Per Container 30 or 60
Amount Per
Serving
% Daily
Value
Vitamin B-6 (as Pyridoxine HCl)
2 mg
100%
Folic Acid
200 mcg
50%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
833%
SAMe (S-Adenosyl L-Methionine)
200 mg
N/A
Percent Daily Values are based on a 2,000 calorie diet.
Other Ingredients:
Cellulose, Croscarmellose Sodium, Methacrylic Acid, Magnesium Stearate (vegetable source), Silica, Triethyl Citrate, Stearic Acid (vegetable source), Citric Acid and Ascorbic Acid.
Contains no: Sugar, salt, starch, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian/Vegan Product.
Caution
Do Not Eat Freshness Packet. Keep in Bottle.
Warning
Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.
Disclaimers
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Store in a cool, dry place.
The products and the claims made about specific products on or through this site have not been evaluated by Fit Shop™, Fitshop.ca or the Canadian Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem Fit Shop™, Fitshop.ca is not responsible for any statements or claims that various manufacturers make about their products or the general information provided for each product on this website. We cannot be held responsible for typographical errors or product formulation changes. Please consult with your own physician or health care practitioner regarding the suggestions and recommendations made at Fit Shop™, Fitshop.ca and especially before using any product sold on this website.
Serving Size 1 Tablet
Servings Per Container 30 or 60
| Amount Per Serving |
% Daily Value |
|
|---|---|---|
| Vitamin B-6 (as Pyridoxine HCl) | 2 mg | 100% |
| Folic Acid | 200 mcg | 50% |
| Vitamin B-12 (as Cyanocobalamin) | 50 mcg | 833% |
| SAMe (S-Adenosyl L-Methionine) | 200 mg | N/A |
Cellulose, Croscarmellose Sodium, Methacrylic Acid, Magnesium Stearate (vegetable source), Silica, Triethyl Citrate, Stearic Acid (vegetable source), Citric Acid and Ascorbic Acid.
Contains no: Sugar, salt, starch, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian/Vegan Product.
Caution
Do Not Eat Freshness Packet. Keep in Bottle.
Warning
Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.
Disclaimers
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Store in a cool, dry place.
Details
Now Foods Sam-e Double Strength 400/200mg
NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.*
Dr Oz looked into SAMe Supplements and found that there is some research that shows that it works as well as certain prescription drugs.
SAM-e (S-adenosyl-L-methionine) is not an herb, vitamin, hormone, or dietary nutrient; it is a synthetic form of a chemical that is naturally produced by the human body. SAM-e exists in cells and is involved in a variety of essential biochemical processes, including cell maintenance and nerve function. It is considered to be a metabolite of the essential amino acid L-methionine. SAM-e is also known by many as ademetionine, S-adenosylmethione, SAM, and SAMe.
SAM-e supplements are marketed for use in connection with a variety of conditions including osteoarthritis, depression, fybromyalgia, and liver disease. Many individuals maintain that SAM-e is as effective for pain relief as aspirin, but does not produce the same side effects such as stomach irritation. It is also believed by some people to be more effective for relieveing depression than many common anti-depressants. Since SAM-e is not regulated by the FDA, it does not require a doctor's prescription. However, in other regions such as Europe, SAM-e is sold as a prescription drug for treating depression, arthritis, and liver disease.
SAM-e is normally produced in the liver from the amino acid methionine found in most healthy diets. Both folic acid and vitamin B12 are required for the synthesis of SAM-e, and deficiencies of either of these vitamins may result in low concentrations of SAM-e in the central nervous system. Lower than normal levels of SAM-e have been detected in individuals with liver cirrhosis, heart disease, Alzheimer's disease, and depression.
Suggested Benefits of SAM-e
While healthy people do not need to supplement with SAM-e researchers suggest that many people may benefit from this supplement. Suggested benefits of SAM-e supplementation include the following:
Osteoarthritis. A number of double-blind studies indicate that SAM-e may help individuals with osteoarthritis. Studies show that SAM-e may reduce stiffness, pain and swelling in arthritic joints, as well as improve overall joint health. Results of some studies even go as far as to suggest that SAMe may be as effective in some instances as ibuprofen and naproxen. However, there is no evidence that SAMe will be effective in any form of arthritis other than osteoarthritis.
Liver Cirrhosis. Preliminary research indicates that SAM-e may also be helpful for various liver conditions including cirrhosis. In one trial, people with liver cirrhosis caused by alcoholism who took SAM-e for two years experienced a nearly 50 lower death rate and/or liver transplantation rate, compared with study participant who received a placebo. The results of this trial, however, where not statistically significant. The results of similar trials conducted using people with less severe forms of cirrhosis has yielded more promising results.
Fibromyalgia. Preliminary research suggests that SAM-e may assist those with fibromyalgia. In one double-blind study in which people with fibromyalgia were given supplemental SAM-e showed beneficial effects, such as a decrease in fatigue, pain sensation, and stiffness. Study participants also noted a significant improvement in mood. Notwithstanding, not all studies have reported such beneficial results.
Depression. SAMe may be helpful for promoting mood and emotional well-being and has been used by some people for the treatment of depression. This has resulted in a series of preliminary studies using oral and parenteral SAMe to treat depression. While the results of these studies are promising they are still inconclusive.
Additional research suggests that SAM-e may also be helpful for cholestasis, liver injury due to alcohol, Gilbert's syndrome and migraines. It may also anti-depressant and hepatoprotective activities.
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